Brody's Human Pharmacology 5th Edition Test Bank

Wecker: Brody’s Human Pharmacology, 5th Edition Chapter 02: Pharmacokinetics: Absorption, Distribution, Metabolism, and Elimination Test Bank Multiple Choice 1. Which of the following features of a drug would enhance its uptake in the GI tract? A. Polar B. Water soluble C. Ionized D. Low molecular weight E. Low concentration gradient ANS: D. Of the options given, only a low molecular weight will increase uptake of a drug by the GI tract. 2. Which organ contains predominantly tight intercellular junctions, thereby restricting its uptake of drugs? A. Kidney B. Liver C. Brain D. Heart E. Lungs ANS: C. The brain contains tight intercellular junctions, forming the “blood-brain barrier.” 3. Drugs commonly undergo all of the following types of metabolism in the liver EXCEPT FOR: A. Polymerization B. Conjugation C. Oxidation D. Reduction E. Hydrolysis ANS: A. Polymerization is not a common process by which drugs are hepatically metabolized. 4. Which organ contains predominantly tight intercellular junctions, thereby restricting its uptake of drugs? A. Kidney B. Liver C. Brain D. Heart E. Lungs ANS: C. The brain contains tight intercellular junctions, forming the “blood-brain barrier.” 5. Drugs commonly undergo all of the following types of metabolism in the liver EXCEPT FOR: A. Polymerization B. Conjugation C. Oxidation D. Reduction E. Hydrolysis ANS: A. Polymerization is not a common process by which drugs are hepatically metabolized.