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How does the inherent imprecision of recombination events during immunoglobulin gene rearrangement contribute to the diversity of the immune response?

Recombinational imprecision affects the number of various LV and J units that are included in the final mature chain.

Recombinational imprecision between any pair of LV and J regions provides variation in amino acid sequence during immunoglobulin formation.

Recombinational imprecision between any pair of LV and C regions provides variation in amino acid sequence during immunoglobulin formation.

Recombinational imprecision affects binding of methyl groups to the enhancer between the J and C regions, which initiates an immune response.

 

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