How does the hypothalamic-pituitary axis apply to the thyroid gland? Which hormones are involved?
Hypothalamic pituitary thyroid axis (HPT) for short, aka thyroid homeostasis or thyrotropic feedback control system and which is the part of the neuroendocrine system responsible for the maintaining of body metabolism and to maintain body homeostasis with equilibrium state.
Its functions mainly relied on the hypothalamus, the pituitary gland, and the thyroid gland.
The hypothalamus of the brain responds to less circulating levels of thyroid hormone such as Triiodothyronine, Thyroxine and responds by releasing thyrotropin-releasing hormone (TRH). The TRH activates the pituitary body and to release thyroid-stimulating hormone (TSH). Further TSH, activates the thyroid to release thyroid hormone until levels in the blood comes to equilibrium level. Thyroid hormone exibits negative feedback control over the hypothalamus as well as anterior pituitary, further controlling the release of both TRH from hypothalamus and TSH from anterior pituitary gland