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26) Currently, somatic cell gene therapy 27) With respect to gene therapy vectors, which of the

Question : 26) Currently, somatic cell gene therapy 27) With respect to gene therapy vectors, which of the : 2134353

26) Currently, somatic cell gene therapy:

A. has only been tested in cell culture and animal models

B. is experimental and has never achieved any clinical success.

C. is experimental and has achieved only very limited clinical success.

D. is routine and has been used successfully to treat many diseases.

27) With respect to gene therapy vectors, which of the following is the key advantage of liposomes over viruses?

A. They can be incorporated into endosomes.

B. They do not cause a host immune response.

C. Unlike viral vectors, they allow DNA to enter the host cell nucleus.

D. They enter cells more efficiently than viruses.

28) To create a “safe” viral vector for delivery of genes into human cells, the virus must be engineered to:

A. remove all viral coat proteins.

B. remove all viral genes, replacing them with the human genes to be delivered.

C. remove select viral genes and replace them with the human genes to be delivered.

D. remove the viral genome and coat proteins and replace them with plasmids carrying the human genes to be delivered.

29) The key step in the generation of “safe” (replication-incompetent) viral particles for gene therapy is

A. creation of site-specific mutations in viral genes

B. provision of viral genes on a Y- (psi-) DNA

C. use of a packaging cell line that is not immortalized

D. deletion of the viral reverse transcriptase gene

30) Adenovirus vectors for gene therapy have all of the following characteristics except:

A. they can infect both dividing and nondividing cells.

B. they have a larger capacity for foreign genes than other viral vectors.

C. they are very immunogenic

D. they stably integrate into host chromosomes

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